Polygot

Polygot is a combined preparation that relieves attacks of migraine and headache of vascular genesis. Polygot contains two active substances. Ergotamine normalizes the tone of dilated extracranial arteries. Caffeine accelerates and increases absorption of ergotamine in the intestine. Indications for use. Acute attacks of migraine and similar headaches of vascular genesis.

Pharmacokinetics

Medicinal products Polygot

After oral administration, approximately 62% of ergotamine is absorbed in the GI tract . Maximum plasma concentrations are reached 2 hours after oral administration. Binding to plasma proteins is 98%. Ergotamine is metabolized in the liver to form pharmacologically active metabolites. Ergotamine is excreted mainly with bile both unchanged and as metabolites. Excretion is biphasic, with half-lives of 2.7 hours and 21 hours for I and II phases, respectively.
After oral administration caffeine is absorbed quickly and almost completely. Binding with plasma proteins is 35%. Caffeine is almost completely metabolized in the body. Metabolites are excreted mainly with urine. The elimination half-life is about 3.5 hours.

Directions for use

Polygot should be taken at the beginning of an attack. For the first use a dose of 2 tablets is recommended. If after 30 minutes there is no improvement, take 1 tablet more. The drug can be repeated further at 30 min intervals, not exceeding the maximum daily dose. In subsequent attacks, the initial dose can be increased to 3 tablets, depending on the total dose taken during the previous attacks. The maximum daily dose is 6 mg ergotamine tartrate (6 tablets). The maximum weekly dose is 10 mg ergotamine tartrate (10 tablets).

Side effects

Medicinal products Polygot

Nausea, vomiting, allergic reactions, increased blood pressure. After long-term use, weakness and pain in the extremities, tremor, cardialgia, tachycardia, bradycardia, fibrotic changes in the pleura and retroperitoneal space. Overdose. Symptoms: drowsiness, confusion, tachycardia, dizziness, paresthesia, respiratory center depression, coma. Treatment: gastric lavage, activated charcoal, symptomatic therapy.

Contraindications: Hypersensitivity to one of the components of the drug; peripheral circulation disorder; obliterating vascular disease; CHD or severe arterial hypertension; hepatic or renal failure; sepsis; pregnancy, lactation.

Special Indications:
If symptoms such as numbness of the tips of the fingers or feet occur, the drug should be discontinued immediately and a physician should be consulted. Polygot is used to treat an acute migraine attack, it should not be used for the prevention of attacks or taken frequently for a long time.

Overdose

Symptoms: nausea, vomiting, drowsiness, confusion, tachycardia, dizziness, parasthesias and pain in extremities, respiratory depression, coma.

Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy, vasodilators such as sodium nitroprusside for atrial spasm.